Getting Aggressive with Mesothelioma

by Thomas Ajava

Cancer is a diagnosis nobody wants to hear. Some forms of cancer are easier to deal with than others. Mesothelioma is unfortunately a bad one and often calls for a particular point of reference when it comes to treatment - an aggressive one!

Mesothelioma is a brutal form of cancer because it usually does not manifest until the very late stages of growth. The cancer is associated with exposure to asbestos fibers in the air, but it can take 40 years or more for the cancer to reach late stages of development that show clear signs. This makes it a rare, but very deadly form of cancer.

It goes without saying that you should consult with a Mesothelioma specialist if you are unlucky enough to be diagnosed with this disease. The treatment you receive will reflect your current diagnosis, but it is vital that you realize the nature of the disease will call for a different approach than you usually receive. Most people are told that conservative treatment is the way to go with most disease.

Mesothelioma treatment plans tend to be just the opposite. They are very aggressive because the cancer is usually discovered very late in the process. This means times is of the essence and there is little reason to wait to see how things development. You can expect your physician to have an aggressive plan incorporating chemotherapy, radial therapy and often surgery to remove large growth areas. This can be a shock for many patients who are used to doctors taking a calm, calculated and very slow approach to sitting and watching a health issue develop.

What if all else fails? What if the physician tells you there is no hope? Well, there is. The National Cancer Institute is a government agency that overseas clinical trials for new treatments for various cancers. Mesothelioma is certainly one of the focuses and even has its own section on the website for the agency. Regardless, the NCI can direct you to clinical trials on new Mesothelioma treatments, which means an out of the box approach that might do the trick.

Mesothelioma is a particularly nasty form of cancer. That doesn't mean it can't be beat. Expect an aggressive treatment plan.

About the Author
Thomas Ajava writes for AsbestosLitigationMaryland.com - where you can learn answers to questions like is all Mesothelioma aggressive?

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What is asbestos poisoning?

by Tony Ulrich

Asbestos is known for its distinctive quality to be extremely resistant to heat and fire along with its outstanding durability. It was therefore very popular and widely used by building and construction businesses. Asbestos itself, if it's not damaged or entirely embedded into another material, does not pose a big risk to someone's health. A problem occurs when the microscopically small asbestos fiber particles get airborne and inhaled by a person. The symptoms of asbestos poisoning, such as dry cough, chest pain and shortness of breath, are deceiving as they are very similar to less serious conditions.

Further to that asbestos poisoning is known for having a long latency period. And that makes the diagnosis even more difficult, because by the time the problem is being addressed, the patient's condition has often gotten worse already. Many homes, especially if they were built before 1980, still contain asbestos ceiling in their living and bedrooms. Furthermore, asbestos was liberally used in pipe insulation, house sidings, roof shingles, floor tiles and in fireproof areas.

Asbestos poisoning is typically the successor to more serious diseases such as mesothelioma, asbestosis or certain forms of lung cancers. Mesothelioma is a rare form of cancer and has a rather poor overall diagnosis.

It is critical to every homeowner who is concerned that he and his family might be exposed to this hazardous material, has asbestos testing done as early as possible. It is strongly recommendable not to remove any asbestos products in a do it yourself approach. There are professional asbestos removing companies available that offer their services and are sufficiently equipped to carry out the job in a safe and timely manner.

Having the asbestos removed by experts is certainly more costly; however, the money you will spend on that is nothing in comparison to dealing with asbestos poisoning or even worse, mesothelioma.

About the Author
The author Tony Ulrich was diagnosed with kidney cancer in October of 2009. In his research on what his cancer could have been caused by, he came across with data that suggests a strong link to environmental toxics, such as asbestos. Please visit his Kidney Cancer and Mesothelioma Info Asbestos website for more details.

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Mesothelioma Patient Advice

A peritoneal mesothelioma patient offers support and encouragement to others facing a mesothelioma diagnosis.

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Researchers demonstrate the safety of potential vaccine against mesothelioma

Researchers have demonstrated the safety of a potential vaccine against mesothelioma, a rare cancer associated primarily with asbestos exposure. The vaccine, which infuses uses a patient's own dendritic cells (DC) with antigen from the patient's tumor, was able to induce a T-cell response against mesothelioma tumors.

The findings have been published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The U.S. and other developed countries have prohibited the use of asbestos for decades, but the time between asbestos exposure and diagnosis of mesothelioma can up to 50 years. The incidence of mesothelioma, therefore, is still on the rise and expected to continue to increase until 2020. Once diagnosed, mesothelioma has a median survival time of 12 months. The standard chemotherapeutic treatment only improves survival time by about three months.

The anticipated increase in the incidence of mesothelioma, together with the paucity of treatment options, has spurred considerable interest in the development of new therapies. Immunotherapy, which uses the body's own immune system to target and destroy cancer cells, has been shown to have some promise.

Building upon their previous research which demonstrated that DC vaccinations induced anti-tumor immunity and conferred a survival benefit in mice, Dr. Aerts and colleagues sought to test the clinical relevance of their finding. After recruiting 10 human patients recently diagnosed with malignant pleural mesothelioma of the epithelial subtype, they cultured immature DC from their blood and exposed the DC to the antigen produced by the patients' tumors. The DC were also exposed to keyhole limpet hemocyanin (KLH), which was used as a surrogate marker to show an immune response. The DC were then matured and injected back into the patients in three doses over a two-week interval.

Serum samples from all patients showed a significant increase of pre- versus post-vaccine antibodies to KLH. In the four patients whose tumor material was sufficient for testing, there was clear induction of cytotoxicity against their own tumors after vaccination. Three patients showed signs of tumor regression, though this could not be conclusively or directly attributed to the vaccine.

Encouragingly, while eight of the patients developed flu-like symptoms in response to the vaccinations, the symptoms normalized after one day in all but one of the patients. There were no signs of autoimmune diseases in the patients provoked by the vaccination, nor other serious side effects.

"The major problem in mesothelioma is that the immunosuppressive environment caused by the tumor will negatively influence our therapy so we are now working on a method to lower this immunosuppressive environment," said Dr. Aerts, a pulmonary physician at Erasmus Medical Center in the Netherlands. "We hope that by further development of our method it will be possible to increase survival in patients with mesothelioma and eventually vaccinate persons who have been in contact with asbestos to prevent them from getting asbestos related diseases."

Source: American Thoracic Society

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How Serious is Mesothelioma?

By the time most infected people become aware they have mesothelioma, it is no longer dormant and becomes extremely aggressive. In its active phase, mesothelioma can travel quickly, and is almost impossible to stop. There are treatments used to keep the patient comfortable, but there is currently no cure for mesothelioma. As many as 75% of those who develop the disease will lose their life within one year. The remainder may last for up to an additional six months.

This makes it extremely important to detect the disease before it enters its active phase.

How is mesothelioma diagnosed?
Mesothelioma is often not diagnosed until it reaches an advanced stage. This is because of its long dormancy period, and because once it becomes active the initial symptoms are similar to much more comman and less dangerous sicknesses such as colds or the flu. If a patient has a history of exposure to asbestos, then a complete physical examination is advised. This would normally include x-rays of the chest or abdomen and lung function tests. It might also include a CT (or CAT) scan or an MRI. Both of these tests give detailed pictures of areas inside the body.

If these tests indicate the probability of mesothelioma, then it is necessary to perform a biopsy to confirm the diagnosis. Doing a biopsy involves an oncology specialist taking a small sample of affected tissue and examining it under a microscope for signs of malignancy. Depending on the location of the affected tissue, doing a biopsy can be a relatively traightforward procedure. It normally involves the insertion of a small instrument into the suspect cavity. These surgical devices have both viewing and sample taking capabilities. So the oncologist or surgeon can look at the cavity from the inside, and then take tissue samples from different areas.

If mesothelioma is discovered, the initial tests are followed up with what is called "staging". This involves more tests to determine how far the disease has spread.

How is mesothelioma treated?
Standard treatments include the normal options available to cancer patients: surgery, radiation therapy, and chemotherapy. Sometimes, these treatments are combined. If the mesothelioma is discovered at an early enough stage these treatments can sometimes be effective.

Among the treatments that are used in order to reduce the effects of the disease are oxygen, postural drainage and pain killers. Many alternative treatment methods are also being tested, including attempts to strengthen the body's immune system. Gene therapy is also being tested in an attempt to attack the problem at the DNA level. Other treatments being tried and tested include homeopathy, herbs and acupuncture. Unfortunately none of these have been found to be very effective once the disease reaches its aggressive stage.

As with all cancers, early detection is the best defense against mesothelioma. Anyone who has been exposed to asbestos should be alert for symptoms and contact a doctor immediately. Detecting mesothelioma at the earliest stage possible greatly increases the chances of beating the disease.

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