Mesothelioma and ongoing research

Mesothelioma is one of the cancers where the survival rate of the victims is very less. Successful treatment is wholly dependent on how early it is diagnosed, but what makes the diagnosis difficult is the subtle nature of the symptoms in its early stages and only in the advanced stages the cancer shows up. So treating mesothelioma is mainly dependent on how early the disease is diagnosed.

 The traditional treatments have been so ineffective in treating mesothelioma and none of them were able to increase the survival rate of the victims by more than a few months. Mesothelioma research foundation of America is very focused on developing new and innovative treatments for this cancer. Some of them include

1)      New chemotherapy agents
2)      Intensity modulated radiation therapy (IMRT)
3)      Immunotherapy
4)      Gene therapy

It is good to know that research has been going in this field for treating mesothelioma. The regulation in United States has immensely helped in reducing the number of cases but countries around the world are still playing catch up game.  They are still letting people mine asbestos and affecting their lives and putting them at risk of this cancer. Science has come off ages in past couple of decades but there is still lot of things left on the table for it to conquer.
I will detail on each of the treatments mentioned above in my future postings.

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Chemotherapy for Mesothelioma

Chemotherapy is a treatment in which doctors use drugs on patients which kills the cancer cells. Chemotherapy for mesothelioma can be used in different situations such as


1) To minimize the tumor before surgery

2) To kill remaining cancer cells after surgery

3) To kill cancer tumor that recurs

4) To use on patients who are not surgical candidates.

Chemotherapy is being continually developed by the researchers. Good news for the mesothelioma patients is that, there is considerable progress is the systematic treatment of this disease in last few years. Pemetrexed is seen as the most promising drug to treat mesothelioma. This is an inhibitor of proteins including thymidylate synthase and dihydrofolate reductase which are required in synthesis of DNA.

Chemotherapy drugs are often used in combination of others and this process is called combination therapy. When cancer occurs, bad cells in the body keep growing as exponential rate and the anticancer drugs can help the bad cells keep in control and during the process good cells may also get damaged which is the main reason for side effects. The cells most likely to be affected are the fast-growing normal cells such as the blood cells forming in bone marrow, and cells in the digestive tract which includes the mouth, stomach, intestines, and esophagus. Hair follicles may also be affected, hence, hair loss during chemotherapy. Some drugs affect cells of vital organs, such as the heart, kidney, bladder, lungs, and nervous system.

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